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Direktoratet for medisinske produkter (tidligere Statens legemiddelverk) har ansvaret for bytteordningen, og har konkretisert vilkårene for hva som regnes for tungtveiende medisinske grunner for et medisinbytte. Melatonin er et hormon som utskilles fra epifysen (corpus pineale), en liten struktur dypt inni hjernen. Melatonin er «mørkets hormon�